نمایش مختصر رکورد

Therapeutic Potential of Glucose Regulated Protein 78 in Cancer

dc.contributor.authorAghamollaei, Hossseinen_US
dc.contributor.authorMousavi Gargari, Seyed Latifen_US
dc.contributor.authorGhanei, Mostafaen_US
dc.date.accessioned1399-07-09T02:23:29Zfa_IR
dc.date.accessioned2020-09-30T02:23:29Z
dc.date.available1399-07-09T02:23:29Zfa_IR
dc.date.available2020-09-30T02:23:29Z
dc.date.issued2015-12-01en_US
dc.date.issued1394-09-10fa_IR
dc.date.submitted2015-09-15en_US
dc.date.submitted1394-06-24fa_IR
dc.identifier.citationAghamollaei, Hosssein, Mousavi Gargari, Seyed Latif, Ghanei, Mostafa. (2015). Therapeutic Potential of Glucose Regulated Protein 78 in Cancer. Journal of Applied Biotechnology Reports, 2(4), 305-310.en_US
dc.identifier.issn2322-1186
dc.identifier.issn2423-5784
dc.identifier.urihttp://www.biotechrep.ir/article_69195.html
dc.identifier.urihttps://iranjournals.nlai.ir/handle/123456789/218738
dc.description.abstractEndoplasmic reticulum has a critical role in the synthesis and folding of secretory and membrane proteins. High accumulation of proteins in ER activates the unfolded protein response and glucose regulated protein 78 or GPR78 plays an essential role in this pathway.  Unfolded protein response is activated in cancerous cells due to their adverse condition to survive and it has been shown that GRP78 can be expressed in tumor cell membrane. Overexpresion and localization of GRP78 makes it a suitable target for the treatment of cancer. This review describes cellular localization, biological function, and role of GRP78 in cancer induction. Methods for tumor inhibition via GRP78 are also discussed.en_US
dc.format.extent105
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoen_US
dc.publisherBaqiyatallah University of Medical Sciencesen_US
dc.relation.ispartofJournal of Applied Biotechnology Reportsen_US
dc.subjectGRP78en_US
dc.subjectBiological Functionen_US
dc.subjectcanceren_US
dc.subjectTumoren_US
dc.titleTherapeutic Potential of Glucose Regulated Protein 78 in Canceren_US
dc.typeTexten_US
dc.typeReview Articleen_US
dc.contributor.departmentApplied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iranen_US
dc.contributor.departmentDepartment of Biology, Faculty of Basic Science, Shahed University, Tehran Iranen_US
dc.contributor.departmentChemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iranen_US
dc.citation.volume2
dc.citation.issue4
dc.citation.spage305
dc.citation.epage310


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