Granulosa Cell Tumor-like Variant of Endometrioid Carcinoma of the Ovary with Osseous Metaplasia: Report of a Rare Case

Abstract

The sex cord-like variant of endometrioid carcinoma is a rare subtype with a close histological resemblance to the sex cord-stromal tumor of the ovaries, in particular the Sertoli cell tumor. However, very few cases of the granulosa cell tumor-like variant have been reported since it is commonly misdiagnosed as a granulose cell tumor. Immunohistochemistry is useful in the diagnosis of these tumors as they are typically negative for inhibin alpha. We herein describe the histological and immunohistochemical features of a rare case of granulosa cell tumor-like variant of endometrioid carcinoma of the ovary with extensive areas of hyalinization, calcification and osseous metaplasia in a 45-year-old female patient.