Gout is a prevalent rheumatic disorder arising from elevated uric acid levels in the bloodstream, a condition known as hyperuricemia. Uricase serves the purpose of reducing uric acid levels nevertheless, it is absent in ...

In the current landscape of drug discovery, various docking programs for virtual database screening significantly reduce costs and time. This study re-docked twenty-three inhibitors of glycogen phosphorylase (GP), a key ...

This study employed advanced computational methods, including semi-empirical parametric method 3 (PM3) and density functional theory (DFT), to investigate the host/guest inclusion complexes of β-cyclodextrin (β-CD) with ...

In this work, molecular docking was performed to evaluate the anticancer activities of cannabidiol on various targeted proteins. Interactions and significant binding energy prove that cannabidiol can be synthesized and ...

Drug delivery based on nanocages is helpful in nanomedicine with the minimum side effects and targeting drugs in the cancer cell. Bendamustine, an anti-cancer drug, inhibits the activity of cancer cells in humans and is ...

The chemical and biological pathways for acetic acid production involve the separation of acetic acid from water. Azeotropic distillation and liquid-liquid extraction are used to separate acetic acid from water with ...

Tuberculosis (TB) is one of the top ten causes of mortality worldwide, necessitating the discovery of new molecules with potential anti-tuberculosis activity. In this study, Pretomanid derivatives as potent anti-TB agents ...

Flavonoids have a broad area of anatomical interest and as such, it is vital to understand their association behaviour with proteins. Here, under biological conditions, the interaction of 2ʹ-hydroxyflavanone (2HF) with ...

This study presents experimental measurements of tie-line and solubility points for the ternary mixtures (water + lactic acid + propylene carbonate) at temperatures of 298.2 and 308.2 K and 101.7 kPa. HPLC measurements ...

This comprehensive study delves into the inhibitory properties of various natural flavonoids against cyclooxygenase-2 (COX-2), a crucial enzyme in the inflammatory pathway. Non-steroidal anti-inflammatory drugs (NSAIDs) ...

To enhance the electrical and optical properties of zirconium dioxide for industrial applications, we conducted a study investigating the influence of two transition metals on the characteristics of monoclinic ZrO2. The ...

Photostabilizing polymeric materials is vital in safeguarding against aging and ultraviolet (UV) irradiation. Consequently, the modification of polymers to enhance their resilience to photodegradation and photooxidation ...

The ALK tyrosine kinase receptor is a promising target in lung cancer. To estimate ALK-TK inhibitory activity, we used QSAR modeling on heterocyclic compounds with varied structures and a large dataset of 1329 chemicals ...

The present study has been conducted to discover a new inhibitor against lung cancer. A large database comprising more than 500,000 molecules was explored. ADME-Tox study was performed to narrow down the selection to 20,000 ...

In this study, the solubility of clonazepam (CZP) in binary solvent mixtures of (1-propanol + water) and (2-propanol + water) at five different temperatures was investigated. The solubility of CZP was assessed using the ...