Mathematical Analysis of Drug Release for Gastrointestinal Targeted Delivery Using β-Lactoglobulin Nanoparticle

Abstract

To answer challenge of targeted and controlled drug release in oral delivery various materials were studied by different methods. In the present paper, controlled metal based drug (Pd(II) complex) release manner of β‑Lactoglobulin (β-LG) nanoparticles was investigated using mathematical drug release model in order to design and production of a new oral drug delivery system for gastrointestinal (GI) tract. The β-LG nanoparticles containing Pd(II) complex were fabricated in the presence of low methoxyl pectin (LMP) at different conditions. Characterization of β-LG nanoparticles using dynamic light scattering (DLS) and atomic force microscopy (AFM) were performed. The <em>in vitro</em> drug release studies were carried out at 37 °C during 8 h in the simulation conditions of GI fluid. The obtained results were fitted in various kinetically release models. The Korsmeyer-Peppas model was evaluated the best describe of each simulation conditions such results indicated an anomalous diffusion manner for drug release. The release data were fitted to the Kopcha model; then, using statistically evaluation revealed that β-LG nanoparticles-LMP complex contain Pd(II) complex dramatically sensitive to pH. In addition, results indicated that for drug release from β-LG nanoparticles delivery system erosion is predominate. So, the erosion-controlled is drug release mechanism of this delivery system. We concluded that β-LG nanoparticles complex with LMP based on mathematical drug release model would be a targeted and practical promising device for GI drug delivery.