Detection of VIM- and IMP-type Metallo-Beta-Lactamase Genes in Acinetobacter baumannii Isolates from Patients in Two Hospitals in Tehran
(ندگان)پدیدآور
Davoodi, SabaBoroumand, Mohammad AliSepehriseresht, SaeedPourgholi, Leilaنوع مدرک
TextBrief Report
زبان مدرک
Englishچکیده
Background: Acinetobacter baumannii, is an opportunistic pathogen and is responsible for numerous nosocomial infections. In recent years, this microorganism has been resistant to a wide range of antibiotics. One of the most important mechanisms of resistance in this microorganism is production of metallo-beta-lactamases (MBLs). Objectives: The aim of this study was to detect VIM- and IMP-type metallo-beta-lactamase genes in Acinetobacter baumanniiisolates from patients in two Hospitals in Tehran. Materials and Methods: 104 isolates were tested using the PCR method for the identification of VIM- and IMP-type genes. Results: vim1, vim2, imp1and imp2 genes were detected in 6.7%, 41.7%, 50% and 1.7% of the isolates from Tehran Heart Center, and in 29.5%, 38.6%, 4.5% and 4.5% of the isolates from Shahid Mutahhari Hospital respectively. Discussion: Our analysis revealed that the majority of the isolates had at least one of these genes, indicating that MBLs production is an important resistance mechanism in Acinetobacter baumannii.
کلید واژگان
Acinetobacter baumanniiImp1
Imp2
Metallo-beta-lactamase
Vim1
Vim2
Molecular Biotechnology
شماره نشریه
1تاریخ نشر
2015-03-011393-12-10
ناشر
National Institute of Genetic Engineering and Biotechnologyسازمان پدید آورنده
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Molecular Pathology, Tehran Heart Center, Tehran University of Medical Science, Tehran, Iran
Department of Molecular Pathology, Tehran Heart Center, Tehran University of Medical Science, Tehran, Iran
Department of Molecular Pathology, Tehran Heart Center, Tehran University of Medical Science, Tehran, Iran
شاپا
1728-30432322-2921