Synthesis of 3,4-Dihydroquinoxalin-2-Amine, Diazepine-Tetrazole and Benzodiazepine-2-Carboxamide Derivatives with the Aid of H6P2W18O62/Pyridino-Fe3O4

Abstract

<em>In the current study, a magnetic inorganic–organic nanohybrid material (HPA/TPI-Fe₃O₄) was produced and used as an efficient, highly recyclable and eco-friendly catalyst for the one-pot and multicomponent synthesis of 3,4-dihydroquinoxalin-2-amine, diazepine-tetrazole and benzodiazepine-2-carboxamide derivatives with high yields and in a short range of time (20–35 min). The nanohybrid catalyst was prepared by the chemical anchoring of H₆P₂W₁₈O₆₂ onto the surface of modified Fe₃O₄ NPs with N-[3-(triethoxysilyl)propyl]isonicotinamide (TPI) linker.The magnetically recoverable catalyst was easily recycled at least ten times without any loss of catalytic activity. The structures of obtained products are certified by ¹H and ¹³C NMR spectra.</em>