Selective Potentiometric Sensor for Isoniazid Ultra-Trace Determination Based on Fe3O4 Nanoparticles Modified Carbon Paste Electrode (Fe3O4/CPE)

Abstract

<em> Significant effects of magnetic iron oxide (Fe₃O₄) nanoparticles on the potentiometric behavior of carbon paste electrode for bio determination of Isoniazid aromatic drug (INH) were studied. The electrochemical performance of modified Fe₃O₄/CPE was investigated. The constructed Fe₃O₄/CPE showed high precision, sensitivity and selectivity, for successfully determination of ultra-trace concentration of INH samples. In this research, pH effects, optimal condition for electrode and interfering Ions, on electrode response were investigated. The best potential response for Fe₃O₄/CPE was obtained with electrode composition of 0.012 g magnetic NPs, 0.006 g silicon oil and 0.060 g graphite powder at pH 6.5 and showed such a low detection limit as 3.09×10⁻¹³ mol L⁻¹ INH.</em>