نمایش مختصر رکورد

dc.contributor.authorHamid Tofighien_US
dc.contributor.authorHamidreza Azimien_US
dc.contributor.authorTooba Ghazanfarien_US
dc.contributor.authorBaharak Eshghipouren_US
dc.contributor.authorSeyed Hossein Bassiren_US
dc.date.accessioned1399-12-04T18:42:40Zfa_IR
dc.date.accessioned2021-02-22T18:42:41Z
dc.date.available1399-12-04T18:42:40Zfa_IR
dc.date.available2021-02-22T18:42:41Z
dc.date.issued2020-03-24en_US
dc.date.issued1399-01-05fa_IR
dc.date.submitted2020-07-01en_US
dc.date.submitted1399-04-11fa_IR
dc.identifier.citationHamid Tofighi, Hamidreza Azimi, Tooba Ghazanfari, Baharak Eshghipour, Seyed Hossein Bassir. (2020). Cytotoxicity Evaluation of Madrepora Coral on Peripheral Blood Mononuclear Cells. Regeneration, Reconstruction, and Restoration, 5, e14-e14. doi: 10.22037/rrr.v5i.31185en_US
dc.identifier.issn2476-5163
dc.identifier.issn2476-5171
dc.identifier.urihttps://dx.doi.org/10.22037/rrr.v5i.31185
dc.identifier.urihttps://journals.sbmu.ac.ir/tripleR/article/view/31185
dc.identifier.urihttps://iranjournals.nlai.ir/handle/123456789/767438
dc.description.abstractIntroduction: The mineral skeleton of corals possesses physical and chemical properties that could resemble the matrix of human bone. It is crucial to evaluate the cytotoxicity of the coral before utilizing it in clinical settings. The present study aimed to assess the cytotoxicity of Madrepora coral on peripheral mononuclear blood (PBM) cells. Materials and Methods: Different concentrations (50, 20, 10, 5, 2, 1 and 0.5 mg/ml) of coral powder were prepared. 96-well plate containing PBM cells, culture medium, and different concentrations of the coral powered was incubated in 37° C  with 5% CO2 for  24, 48, 72 hours. The cell viability was evaluated using MTT assay. Results: After 24 h, only 50 mg/ml dose of the coral significantly decreased the viability of PBM cells compared to the control group. After 48 h, 20 mg/ml and 50 mg/ml doses significantly decreased the viability of PBM cells (P < 0.05). After 72 h, the viability of PBM cells was significantly decreased with 10 mg/ml, 20 mg/ml, and 50 mg/ml doses (P < 0.05). Conclusion: It can be concluded that the Madrepora coral has low toxicity for mononuclear peripheral blood cells in high doses, and it can be a candidate for implantation in human as a bone substitute.en_US
dc.format.extent2102
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoen_US
dc.relation.ispartofRegeneration, Reconstruction, and Restorationen_US
dc.relation.isversionofhttps://dx.doi.org/10.22037/rrr.v5i.31185
dc.subjectBone defecten_US
dc.subjectBone Substitutesen_US
dc.subjectCoralen_US
dc.subjectCytotoxicityen_US
dc.subjectDental implanten_US
dc.subjectMadreporaen_US
dc.subjectMTTen_US
dc.subjectPeripheral blood cellsen_US
dc.titleCytotoxicity Evaluation of Madrepora Coral on Peripheral Blood Mononuclear Cellsen_US
dc.typeTexten_US
dc.citation.volume5
dc.citation.spagee14
dc.citation.epagee14


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