Quantitative and Qualitative Scintigraphic Measurement of Renal Function in Persian Cat Using 99mTechnetium Ethylenedicysteine and 99mTechnetium Diethylenetriaminepentaacetic

Abstract

Objective- To consider the use of renal scintigraphic evaluation of kidney function in Persian cat and make a comparison between ^99mTechnetium ethylenedicysteine and ^99mTechnetium diethylenetriaminepentaacetic in renal scintigraphy.<br /> Design- Descriptive study<br /> Animals- 6 male healthy adult Persian cats - no clinical sign of renal disorders and prior to presentation.<br /> Procedure- The scintigraphy of right and left kidney using Gamma camera (Piker Model) and ^99mTc-EC and ^99mTc-DTPA as radiopharmaceuticals. Peak activity percentage (% PA), peak time (T_max), half emptying-time (T_1/2), total and individual GFR and flow and function time activity curves (TACs) are the determined parameters in this evaluation.<br /> Results- % PA, T_maxand T_1/2in left and right kidney for ^99mTc-EC and ^99mTc-DTPA respectively, were 49/86 %, 50/1 %, 11/3 min, 11/5 min, 4/4 min, 4/6 min and 51/27 %, 49/05 %, 7/7 min, 8/3 min, 3 min, 3/43 min.<br /> Moreover the quantities of total and individual GFR for left and right kidney measured by ^99mTc-DTPA measured by modified Gates technique respectively, were 125/69 ml/min, 64/42ml/min (51/26 %), 61/24ml/min (48/73 %) and were in normal range defined by Gates technique.<br /> Conclusion and Clinical Relevance- normal indices obtained for listed parameters and total and individual GFR quantities can play a major role in order to diagnose kidney disorder or function deterioration and can be a background and specialized knowledge conducive to future studies.<br /> Also comparison of two radiopharmaceuticals ^99mTc-EC and ^99mTc-DTPA showed that ^99mTc-DTPA scintigraphy has the superiority to assess the quantities of total and individual GFR so we can use ^99mTc-DTPA to evaluate Glomerular filtration rate in both kidneys.