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    • Addiction and Health
    • Volume 12, Issue 4
    • مشاهده مورد
    •   صفحهٔ اصلی
    • نشریات انگلیسی
    • Addiction and Health
    • Volume 12, Issue 4
    • مشاهده مورد
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    Effect of Magnesium Sulfate Added to Tincture of Opium and Buprenorphine on Pain and Quality of Life in Women with Dysmenorrhea: A Prospective, Randomized, Double-blind, Placebo-controlled Trial

    (ندگان)پدیدآور
    Pirnia, BijanMasoudi, RahelehPirnia, KambizJalali, MinaEslami, Mohammad RezaMalekanmehr, ParastooPirnia, FariborzAjori, Ladan
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    نوع مدرک
    Text
    Original Article
    زبان مدرک
    English
    نمایش کامل رکورد
    چکیده
    Background: Adding magnesium sulfate (MgSO4) to opioid receptor agonists increases the opioid analgesiceffects via blocking this receptor. The current study aimed to evaluate the effectiveness of adding MgSO4 totincture of opium (TOP) and buprenorphine (BUP) on pain and quality of life (QOL).Methods: In prospective, randomized, double-blind, placebo-controlled clinical trial, one hundred andsixty-three women with secondary dysmenorrhea caused by endometriosis were selected using a respondentdriven sampling (RDS) and assigned into six groups using block randomization. Patients received 50 mg/kgMgSO4 in 100 ml saline by micro set in six monthly menstrual periods and completed the visual analoguescale (VAS) and QOL Questionnaire (QOLQ). Data were analyzed by repeated measures analysis of variance(ANOVA) and hierarchical regression.Findings: The primary outcomes showed that pain scores in magnesium (MAG) + opium tincture (OT)[F = 5.7(1,162), P = 0.004] and MAG+ BUP [F = 4.5(1,162), P = 0.006] groups showed a significant decreasecompared with control group. Also, QOL scores in MAG + OT [F = 4.8(1,162), P = 0.005] and MAG + BUP[F = 5.9(1,162), P = 0.003] showed a significant increase. However, there was no significant differencebetween the two groups (P = 0.140) and the changes did not persist until follow-up (P = 0.810). Secondaryoutcomes indicated that the low scores of the two components of QOL including physical and psychologicalcomponents were predictors of pain (P = 0.011, Beta > 3.09).Conclusion: Simultaneous use of MAG with opioids is associated with pain reduction and the improvement ofQOL. However, this hypothesis requires careful handling in a randomized controlled trial
    کلید واژگان
    Dysmenorrhea
    Endometriosis
    Pain
    magnesium sulfate
    Buprenorphine

    شماره نشریه
    4
    تاریخ نشر
    2020-10-01
    1399-07-10
    ناشر
    Kerman University of Medical Sciences
    سازمان پدید آورنده
    Department of Psychology, School of Humanities, University of Science and Culture AND Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Department of Midwifery, School of Medicine, Qom Branch, Islamic Azad University, Qom, Iran
    Bijan Center for Substance Abuse Treatment, Tehran, Iran
    Department of Psychology, Kish International Branch, Islamic Azad University, Kish, Iran
    Department of Health Psychology, North Tehran Branch, Islamic Azad University, Tehran, Iran
    Department of Psychology, School of Psychology, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
    Department of Food Science and Technology, School of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
    Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    شاپا
    2008-4633
    2008-8469
    URI
    https://dx.doi.org/org/10.22122/ahj.v12i4.285
    http://ahj.kmu.ac.ir/article_91539.html
    https://iranjournals.nlai.ir/handle/123456789/709523

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