Antimicrobial Activity of Salvia officinalis Acetone Extract against Pathogenic Isolates

Abstract

Background & Aim: <em>Salvia officinalis</em> is known as a traditional medicine for several diseases in countries like Lebanon, Syria, Jordan, etc. In addition, <em>S. officinalis</em> has been subjected to several studies in a try to specify its medicinal effects. This study aims to evaluate the antimicrobial activity of this plant. The aim of the present research was to study antibacterial effects of <em>S. officinalis</em> on some bacteria. Experimental: Three solvent extracts (de-ionized distilled water, Acetone, and Ethanol) of the plant were investigated against <em>Bacillus anthracis, Bacillus cereus, Escherichia coli, and Staphylococcus aureus</em> by using disc diffusion method. Results & Discussion: Ethanol extracts showed moderate antimicrobial effect, while acetone extracts showed the most powerful antimicrobial effect, especially acetone leaves extracts. However, the de-ionized distilled water extracts showed no antimicrobial activity against the bacteria tested. The results indicate the inhibitory effects of acetone extract of <em>S. officinalis</em> with MIC= 10 mg/ml for <em>B. anthrac</em>is and MIC=30 mg/ml for <em>S. aureus</em>. Gram-negative microorganisms presented larger sensitivity for the extracts. As a result, organic solvent extracts (especially acetone leaves extracts) of this plant can be used as natural antimicrobial product. Results are in the aid of the fact as the polarity of the solvent decreases the antimicrobial compounds, and hence activity of the extracts, increases. Industrial and practical recommendations: <em>Salvia officinalis </em>extract can be used as ointment for wound treatment. Science this extract has activity against <em>B. anthracis </em>we can introduce a new drug for <em>B. anthracis.</em>