The Effect of Dusts on Liver Enzymes and Kidney Parameters of Serum in Male Rats in Khuzestan, Iran

Abstract

The present study aimed to investigate the effect of dusts on rat specimens in Southern Iran, Khuzestan, focusing on serum enzymes (Alpha-Amylase, Alkaline phosphatase, Alanine transaminase, Lactate dehydrogenase, and Aspartate transaminase) and kidney parameters (creatinine and urea). The study was conducted on 30 adult male rats that were divided into six groups, including one as the control group, and five as the experimental groups (Ahvaz, Ramhormoz, Andimeshk, Abadan, and Susangerd). Results showed that alanine aminotransferase increased in the groups of Ramhormoz, Andimeshk, Abadan, and Susangerd while Ahvaz showed a decrease. Alkaline phosphatase activity in all treated groups showed a significant increase compared to the control group. The activity of lactate dehydrogenase decreased in all samples, but only in Ahvaz and Susangerd groups it was significant compared to control group. Alpha-amylase activity was significantly increased in the groups of Ramhormoz, Andimeshk, Abadan, but decreased significantly in Ahvaz group, indicating a different value of harmful substances in dust particulates of these five cities. Serum urea level increased in all groups except Ahvaz, which was only significant in the group of Ramhormoz. Also, creatinine level decreased in all groups except Ahvaz. The results of this study showed that, the effect of fine dust was more evident in three cities of Ahvaz, Andimeshk and Ramhormoz due to the large amounts of total concentrations of heavy metals. Also, both the liver and the kidney were affected by both particulate matter, but it seems that the effect on the liver was more than the kidney.