Stage IE Primary Bone Lymphoma:Limb Salvage for Local Recurrence

Abstract

Background: <br/> <br/><span style="font-size: xx-small; font-family: ArialMT;">Primary bone lymphoma or non-Hodgkin lymphoma of bone is a rare disease. There are only a few</span> <br/>case series of stage IE of this condition in medical literature. The aim of this study is to determine the rate of survival <br/> <br/>for stage IE after combined modality treatment, the rate of local recurrence, and the results of limb salvage in cases <br/> <br/>of local recurrence. <br/> <br/> <br/>Methods: <br/> <br/><span style="font-size: xx-small; font-family: ArialMT;">We collected data from 61 patients with histologically confirmed PBL treated at the Musculoskeletal</span> <br/> <br/>Oncology Department of our hospital from 2000 to 2010. Retrospective evaluation included demographics, symptoms, <br/>tumor locations, outcomes of surgical treatment for local recurrence and survival rates. <br/>Results: <br/> <br/><span style="font-size: xx-small; font-family: ArialMT;">All patients received Combined Modality Therapy. Overall,five year survival was 89% and five year disease</span> <br/>free survival rate was 78%. Local recurrence occurred in 6 patients during follow up period, which was treated surgically <br/> <br/> <br/>by wide excision and reconstruction. The mean follow-up for the local recurrence group was 36(24-54) months and <br/>mortality rate in this group was 17%. <br/>Conclusions: <br/> <br/><span style="font-size: xx-small; font-family: ArialMT;">Combined Modality Therapy for stage IE primary bone lymphomaresults in good survival rate. In case</span> <br/> <br/>of local recurrence, wide excision and reconstruction improves the outcomes.