Correlation Between Type II Diabetes Mellitus and Left Atrial Function as Assessed by 2D Speckle-Tracking Echocardiography in Patients Without Coronary Artery Disease

Abstract

<span><strong><em>Background: </em></strong><span>Diabetes mellitus (DM) is associated with several comorbidities and complications<span> such as hypertension, obesity, hyperlipidemia, nephropathy, and cardiovascular diseases.<span> This study aimed to investigate the correlation between the left atrial (LA) function and<span> DM via conventional and speckle-tracking echocardiography (STE).<br /><span><strong><em>Methods: </em></strong><span>In this prospective study, from 198 patients with sinus rhythms, 174 patients were<span> included based on inclusion and exclusion criteria. Conventional and STE examinations<span> were done for all the patients. The patients' demographics, comorbidities, and family<span> history, as well as the results of their angiography or computed tomography angiography,<span> electrocardiography, and echocardiography, were recorded. The variables were compared<span> between the groups with and without DM, and the association between the LA function<span> and DM was studied in the patients.<br /><span><strong><em>Results: </em></strong><span>Totally, 45.2% of the diabetic patients (n = 28) and 38.4% of the nondiabetic patients<span> (n = 30) had diastolic dysfunction (<span><em>P </em><span>= 0.384). The diabetic patients had a lower mean of<span> the left ventricular end-diastolic diameter, the LA peak strain during the reservoir phase,<span> the LA pump, and the LA peak positive strain rate during ventricular systole<span> (all <span><em>P</em><span>s < 0.001) and a higher mean of the left ventricular mass index, the A-wave, the<span> E/A, the LA peak negative strain rate during early diastole (all <span><em>P</em><span>s <0.001), the left<span> ventricular end-systolic volume (<span><em>P </em><span>= 0.001), the Ea (<span><em>P </em><span>= 0.008), the LA ejection fraction<span> (<span><em>P </em><span>= 0.011), and the passive emptying volume (<span><em>P </em><span>= 0.026).<br /><span><strong><em>Conclusions: </em></strong><span>The results of the present study indicated LA and left ventricular dysfunction in<span> diabetic patients. However, the LA function may be affected by several factors, and our<span> nonrandomized patient selection could also have affected the results. Thus, it is suggested<span> that future randomized clinical trials compare the LA echocardiographic parameters in<span> matched groups. </span></span></span><br /></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span>