CD 28 GENE POLYMORPHISM IS NOT ASSOCIATED WITH SUSCEPTIBILITY TO CORONARY ARTERY DISEASE

Abstract

Background: Coronary artery disease (CAD) is one of the most common health problems facing health care services in all societies. Despite the established significance of the classic risk factors for CAD, a large number of patients present without them. It has recently been identified that elevated inflammatory markers and involved immunological mechanisms are associated with atherosclerosis. CD 28 is the main co-stimulatory receptor for secondary signals delivering for T-cell activation. The aim of this study was to evaluate the polymorphism of CD 28 gene as a probable risk factor for CAD.<br />Methods: In total, 200 patients were classified into two equal groups: control group including persons with normal coronary arteries and case group who had at least single-vessel coronary disease. CAD was confirmed in the studied patients by coronary angiography. CD 28 genotype was analyzed via polymerase chain reaction (PCR). <br />Results: The frequencies of C and T alleles were 71% and 29% in the control group and 70.5% and 29.5% in the case group, respectively. There was no significant difference in the allele frequencies between the two groups. <br />Conclusion: We concluded that CD 28 gene polymorphism was not associated with CAD.