Anti-oxidant and anti-hyperlipidemic activity of Hemidesmus indicus in rats fed with high-fat diet

Abstract

<br/><strong>Objective: </strong>Dietary changes playmajor risk roles in oxidative stress andcardiovascular disease and modulate normal metabolic function. The present study was designed to investigate the ameliorative potential of different extracts of <em>Hemidesmus indicus</em> to experimental high-fat diet in wistar rats, and their possible mechanism of action. <br/><strong>Materials and Methods</strong>: Male wistar rats were divided into 6 groups (n=6/group) andfed with a standard diet (control), high-fat diet (HFD), high-fat diet supplemented with different extracts and positive control for 9 weeks. High-fat diet induced changes in average body weight andoxidative stress and elevated levels of plasma lipid profilein rats. <br/><strong>Results</strong>: Oral administration of methanolic extract of <em>H. indicus</em>(200 mg/kg) offered a significant dose-dependent protection against HFD-induced oxidative stress, as reflected in the levels of catalase (p<br/><strong>Conclusion</strong>: The present study revealed that the methanolic extract of <em>H.indicus </em>protects against oxidative stress, hyperlipidemia and liver damage.