The effects of different fractions of Coriandrum sativum on pentylenetetrazole-induced seizures and brain tissues oxidative damage in rats

Abstract

Objective: In the present work, the effects of different fractions of <em>Coriandrum sativum (C. sativum)</em>, on pentylenetetrazole (PTZ)-induced seizures and brain tissues oxidative damage were investigated in rats. <br/>Materials and Methods: The rats were divided into the following groups: (1) vehicle, (2) PTZ (90 mg/kg), (3) water fraction (WF) of<em> C. sativum</em> (25 and 100 mg/kg), (4) <em>n</em>-butanol fraction (NBF) of<em> C. sativum</em> (25 and 100 mg/kg), and (5) ethyl acetate fraction (EAF) of<em> C. sativum</em> (25 and 100 mg/kg). <br/>Results: The first generalized tonic-clonic seizures (GTCS) latency in groups treated with 100 mg /kg of WF or EAF was significantly higher than that of PTZ group (p< 0.01). In contrast to WF, the EAF and NBF were not effective in increasing the first minimal clonic seizure (MCS) latency. Malondialdehyde (MDA) levels in both cortical and hippocampal tissues of PTZ group were significantly higher than those of control animals (p< 0.001). Pretreatment with WF, NBF, or EAF resulted in a significant reduction in the MDA levels of hippocampi (pConclusion: The present study showed that different fractions of <em>C. sativum</em> possess antioxidant activity in the brain and WF and EAF of this plant have anticonvulsant effects.