ASSOCIATION BETWEEN VITAMIN D LEVEL AND ISCHEMIC HEART DISEASE

Abstract

Background: Vitamin D deficiency has been associated with many cardiovascular diseases and mortality.<br />In this study, we aimed to investigate whether low levels of 25 hydroxy vitamin D concentrations associate with ischemic heart disease (IHD) in patients who referred for coronary angiography.<br />Methods: We included 293 subjects: 133 without IHD (normal reported angiography) and 163 with ischemia (70% or more stenosis of at least one coronary artery documented by angiography). Basal concentrations of serum vitamin D, fasting blood sugar, triglyceride, cholesterol, LDL, and HDL were measured in both groups.<br />Results: The two groups had no significant difference in respect to their age (56.55 vs.61.45 years), blood pressure (123.03/73.88 vs.123.68/73.98 mm Hg), fasting blood sugar (114.97 vs.121.49 mg/dl), and lipid profile (P<0.05). The medians of vitamin D concentration in the case and control groups were 40.80 and 40 nmol/lit, respectively, with the difference not constituting statistical significance (P<0.05). After adjusting for other risk factors (age, sex, blood pressure, fasting blood sugar, and lipid profile), the association between vitamin D and ischemia remained non-significant (adjusted OR: 0.83, 95% CI: 0.37-1.85).<br />Conclusion: This study was unable to demonstrate an association between low levels of vitamin D and IHD