Preparation and Characterization of Curcumin-Silver Nanoparticle and Evaluation of the Effect of Poly Ethylene Glycol and Temperature

Abstract

In this research, the silver nanoparticle (AgNP) was rapidly prepared by simple solution method within 1 hour at 25 and 80 °C in the present and the absent polyethylene glycol (PEG). The curcumin-silver nanoparticle was synthesized from silver nitrate as precursor and sodium bore hydrate as a reduction in two conditions included water solvent and polyethylene glycol in water solvent at 25 °C as solution method and 80 °C as thermal method. The agar diffusion method was used for determination of the antibacterial activity of the samples against <em>Escherichia coli</em> (<em>E. coli</em>). The antibacterial properties against <em>E.coli</em> were observed because of the presence of AgNP. Based on the results, the curcumin loading and release was affected by temperature and PEG. The curcumin-AgNP nanoparticle can have a good potential for antibacterial activity and loading and release of the drug.