نمایش مختصر رکورد

dc.date.accessioned1399-07-08T18:15:23Zfa_IR
dc.date.accessioned2020-09-29T18:15:24Z
dc.date.available1399-07-08T18:15:23Zfa_IR
dc.date.available2020-09-29T18:15:24Z
dc.date.issued2014-12-01en_US
dc.date.issued1393-09-10fa_IR
dc.identifier.citation(2014). Interference of Fisetin with Targets of the Nuclear Factor-κB Signal Transduction Pathway Activated by Epstein-Barr Virus Encoded Latent Membrane Protein 1. Asian Pacific Journal of Cancer Prevention, 15(22), 9835-9839.en_US
dc.identifier.issn1513-7368
dc.identifier.issn2476-762X
dc.identifier.urihttp://journal.waocp.org/article_30187.html
dc.identifier.urihttps://iranjournals.nlai.ir/handle/123456789/39817
dc.description.abstractFisetin is an effective compound extracted from lacquer which has been used in the treatment of variousdiseases. Preliminary data indicate that it also exerts specific anti-cancer effects. However, the manner in whichfisetin regulates cancer growth remains unknown. In this study, we elucidated interference of fisetin with targetsof the nuclear factor κB signal transduction pathway activated by Epstein-Barr virus encoding latent membraneprotein 1 (LMP1)in nasopharyngeal carcinoma (NPC) cells, Results showed that fisetin inhibited the survivalrate of CNE-LMP1 cells and NF-κB activation caused by LMP1. Fisetin also suppressed nuclear translocationof NF-κB (p65) and IκBα phosphorylation, while inhibiting CyclinD1, all key targets of the NF-κB signaltransduction pathway. It was suggested that interference effects of fisetin with signal transduction activated byLMP1 encoded by the Epstein-Barr virus may play an important role in its anticancer potential.en_US
dc.format.extent1681
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoen_US
dc.publisherWest Asia Organization for Cancer Prevention (WAOCP)en_US
dc.relation.ispartofAsian Pacific Journal of Cancer Preventionen_US
dc.subjectFisetinen_US
dc.subjectNasopharyngeal carcinomaen_US
dc.subjectlatent membrane protein 1en_US
dc.subjectNF-κBen_US
dc.titleInterference of Fisetin with Targets of the Nuclear Factor-κB Signal Transduction Pathway Activated by Epstein-Barr Virus Encoded Latent Membrane Protein 1en_US
dc.typeTexten_US
dc.citation.volume15
dc.citation.issue22
dc.citation.spage9835
dc.citation.epage9839


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