PPAR-Gamma Pro12Ala Polymorphism and Gastric Cancer Risk in a Turkish Population

Abstract

<b>Background:</b> Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand dependent transcriptionfactor involved in various processes, including carcinogenesis. We aimed to investigate any possible associationof the PPARγ Pro12Ala (rs1801282) polymorphism with risk of developing gastric cancer (GC). Patients and<br/><b>Methods</b>: A hospital based case control study was designed covering 50 patients with GC and 120 healthy controls.The frequencies of PPARγ Pro12Ala (rs1801282) were determined using a polymerase chain reaction-restrictionfragment length polymorphism (PCR-RFLP) assay. <br/><b>Results</b>: The Ala12 allele of the PPARγ Pro12Ala G gene wasassociated with a 1.95 fold increased risk of GC development (p: 0.022; 95% CI: 1.58-2.40). Subgroup analysesshowed that the same allele was also associated with metastasis (p: 0.000; OR:4.09; 95%CI:2.273-7.368) anddifferentiation (p: 0.004; OR:1.95; 95%CI:1.335-2.875) in patients with GC. <br/><b>Conclusion</b>: This study suggeststhat the PPARγ Pro12Ala G (Ala12) allele might be associated with development, differentiation and metastaticprocess of GC in the Turkish population. Further studies conducted in larger study groups and in different ethnicpopulations will be needed to clarify the exact role of the PPARγ Pro12Ala polymorphism in GC.