No Association between the CDX2 G543C Polymorphism and Risk of Gastric Atrophy and Cancer

Abstract

Ectopic expression of CDX2 in the stomach is closely associated with chronic Helicobacter pylori (H. pylori)infection and intestinal metaplasia. Whether CDX2 has tumor suppression or tumorigenesis potential remainsto be elucidated. In this study, we investigated the association between the CDX2 G543C polymorphism (silentmutation) and the risk for H. pylori-induced gastric atrophy and cancer as well as H. pylori infection, using 454Japanese subjects undergoing a health checkup and 202 gastric cancer patients. The frequency of the minor allelewas the same as previously reported in China, but different from that reported in England. CDX2 G543C wasnot associated with risk of H. pylori infection, gastric atrophy, or gastric cancer, although the point estimate fornon-cardiac differentiated gastric cancer as compared to controls with gastric atrophy was 2.22 (95%CI=0.17-29.4). In conclusion, our results indicate that the CDX2 G543C polymorphism is unlikely to affect the H. pyloriinfection-gastric atrophy-gastric cancer sequence.