Expression of HMGB1 and its Clinical Significance in T-cell Lymphoma

Abstract

<br/><b>Objectives</b>: To evaluate the clinical significance of HMGB1 expression in T-cell lymphoma. <br/><b>Methods</b>:Immunohistochemical staining for HMGB1 and survivin was performed with specimens from 120 cases of T-celllymphoma and 40 cases of reactive lymphoid hyperplasia with antibodies against human HMGB1 and survivin.<br/><b>Results</b>: The expression of HMGB1 and survivin was significantly higher in tissues of T-cell lymphoma than inreactive lymphoid hyperplasia. Positive expression of HMGB1 and survivin was observed in 63.7% (65/102)and 61.8% (63/102) of T-cell lymphoma cases, respectively. While was associated with gender, age, and tumorlocation, significant correlations with malignancy and clinical stage were observed. Spearman rank correlationanalysis revealed that the expression of HMGB1 and survivin was positively correlated in T-cell lymphomas(P<0.01). <br/><b>Conclusions</b>: Expression of HMGB1 and survivin in T-cell lymphomas is significantly associated withmalignancy and clinical stage, but not with gender, age and tumor location. Elevated expression of HMGB1 maybe an important biomarker for the development and progression of T-cell lymphoma.