Association of MDR1 Gene Polymorphisms with Susceptibilityto Hepatocellular Carcinoma in the Chinese PopulationAssociation of MDR1 GenePolymorphisms with Susceptibility to Hepatocellular Carcinoma in the Chinese Population

Abstract

<br/><b>Objective</b>: The objective of this study was to evaluate the association of MDR1 gene polymorphisms withsusceptibility to hepatocellular carcinoma (HCC). <br/><b>Methods</b>: A total of 689 HCC patients and 680 cancer-freesubjects were enrolled. Human MDR1 gene polymorphisms were investigated by created restriction sitepolymerasechain reaction (CRS-PCR) and DNA sequencing methods. Multiple logistic regression models wereapplied to estimate the association between MDR1 gene polymorphisms and susceptibility to HCC. <br/><b>Results</b>:We detected a novel c.4125A>C polymorphism and our findings suggested that this variant was significantlyassociated with susceptibility to HCC. A significantly increased susceptibility to HCC was noted in the homozygotecomparison (CC versus AA: OR=1.621, 95% CI 1.143-2.300, χ2=7.4095, P=0.0065), recessive model (CC versusAC+AA: OR=1.625, 95% CI 1.167-2.264, χ2=8.3544, P=0.0039) and allele contrast (C versus A: OR=1.185, 95% CI1.011-1.389, χ2=4.4046, P=0.0358). However, no significant increase was observed in the heterozygote comparison(AC versus AA: OR=0.995, 95% CI 0.794-1.248, χ2=0.0017, P=0.9672) and dominant model (CC+AC versus AA:OR=1.106, 95% CI 0.894-1.369, χ2=0.8560, P=0.3549). <br/><b>Conclusions</b>: These findings suggest that the c.4125A>Cpolymorphism of the MDR1 gene might contribute to susceptibility to HCC in the Chinese population. Furtherwork will be necessary to clarify the relationship between the c.4125A>C polymorphism and susceptibility toHCC on larger populations of diverse ethnicity.