Platelet Indices May be Useful in Discrimination of Benign and Malign Endometrial Lesions, and Early and Advanced Stage Endometrial Cancer

Abstract

<b>Background:</b> The aim of this study was to investigate the predictive value of white blood cells (WBC),the neutrophil to lymphocyte ratio (NLR), platelet indices including mean platelet volume (MPV), plateletdistribution width (PDW), platelet crit (PCT) and platelet to lymphocyte ratio (PLR) in discrimination betweenbenign and malign endometrial lesions, and early and advanced stage endometrial adenocarcinomas. Materialsand <br/><b>Methods</b>: Data for 105 patients undergoing total abdominal or vaginal hysterectomy for benign uterinediseases and 114 patients surgically staged for endometrium adenocarcinoma at Ondokuz Mayis University,Department of Gynecology and Obstetrics, between 2008 and 2014, were collected. Parameters were preoperativeand postoperative complete blood counts in the week prior to surgery with differentials including WBC, plateletcount, platelet indices (MPV, PCT, PDW), NLR and PLR. Pathologic evaluations for both benign and malignendometrium lesions, grade of endometrium adenocarcinoma, tumor stage, presence of lymphovascular spaceinvasion (LVI) were retrospectively analyzed. <br/><b>Results</b>: Regarding definitive factors in discriminating patientswith endometrium cancer from those with benign diseases, MPV was significantly increased in the malign groupwhereas there was a significant decrease in the PDW value compared to the benign group. The best cut-off valuein differentiation of the benign and malign groups, malign cases were found to increase over the value of 7.54for MPV, and under 37.8 for PDW. When definitive factors in discrimination of early stage endometrium cancerfrom advanced stage disease and LVI in the malign group were evaluated according to the ROC analysis, nosignificant relation was detected between blood parameters and the stage and the LVI of the disease. <br/><b>Conclusions</b>:MPV and PDW may have predictive value in the discrimination of benign and malign endometrium diseases.Nevertheless, since there have been few reports on this topic, further large-scale prospective studies are necessary.