Lack of Altered BECN1 Gene Expression in Iranian Patients with Acute Myeloid Leukemia

Abstract

<br /> <span style="font-size: small;">Acute myeloid leukemia (AML), one of the most prevalent leukemia types in adults, demonstrates great heterogeneity in molecular and clinical terms. Hence, there is a necessity to the mechanisms involved in AML generation in order to determine optimal treatment. This cross sectional study aimed to assess changes in BECN1 gene expression in with blood samples from 30 AML patients, compared with samples from 15 healthy persons. RNA was extracted and cDNA </span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">was synthesized and Real Time PCR applied to determine BECN1 gene expression. The results showed no significant </span></span><span style="font-size: small;">differences in BECN1 gene expression between patients with AML and normal controls (P > 0.05). It appears that </span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">expression of BECN1 does not play a significant role in genesis of AML leukemia. </span></span>