Prognostic Significance of Basic Laboratory Methods in Non-Small-Cell-Lung Cancer

Abstract

<b>Background:</b> In our study, the LDH, albumin, hemoglobin, neutrophile, thrombocyte, lymphocyte countsand prognostic significance of neutrophile-lymphocyte and thrombocyte-lymphocyte ratios in NSCLC derivedfrom these counts obtained during regular examinations of patients were examined. Materials and <br/><b>Methods</b>:Histopathologically diagnosed non-small-cell-lung cancer patients between 2008 and 2010 were included inthe study. Before the treatment, full blood count including routine lymphocyte count, blood biochemistryexaminations including liver (AST, ALT, total protein, Albumin), LDH and kidney (BUN, Cre) function testswere performed. <br/><b>Results</b>: A total of 156 patients, 76 of whom (48.7%) were female and 80 of whom (51.3%) weremale were included. Mean hemoglobin level was determined as 12. Overall survival was found to be significantlydependent on whether patients were anemic or not (p: 0.005). Mean LDH level was determined as 233.4. Therewas nosurvival difference between patients with and without high LDH (p: 0.532). In patients where NLR showedsystemic inflammatory response, overall survival was 10.8 months whereas this duration was 19.6 months inpatients where the systemic inflammatory response was negative (p: 0.012). In patients where TLR showedsystemic inflammatory response, overall survival was 13.6 months whereas this duration was 21.9 months inpatients where the systemic inflammatory response was negative (p: 0.04). <br/><b>Conclusions</b>: Molecular methodshave been changing rapidly in today’s world and they manage the treatment besides defining the prognosis ofpatients. However, easily accessible and cheap laboratory parameters should be considered in the prognosis ofpatients besides these new methods.