XRCC1 and ADPRT Polymorphisms Associated with Survival in Breast Cancer Cases Treated with Chemotherapy

Abstract

Aim: To investigate whether XRCC1 and ADPRT polymorphisms might be associated with outcomes ofbreast cancer. <br/><b>Methods</b>: A prospective study was conducted with a total of 335 breast cancer patients undergoingchemotherapy consecutively collected from Jan. 2005 to Jan. 2008. Genotyping of XRCC1 and ADPRTpolymorphisms was conducted by PCR-RFLP assay. <br/><b>Results</b>: All 335 patients were followed up until death or theend of Jan. 2012, with a median follow-up period of 38.8 (2-64) months. It was shown that the variant genotypeof XRCC1 399Gln/Gln was strongly significantly associated with a decreased risk of death from breast cancer,with an HR (95% CI) of 0.52 (0.28-0.91). Similarly, individuals carrying the ADPRT 762Ala/Ala demonstratedlonger survival compared to ADPRT 762 Val/ Val, with an HR (95% CI) of 0.58 (0.31-0.97). Individuals withcombination genotypes of XRCC1 399Gln allele and ADPRT 762Ala/Ala presented with a longer survival, theHR (95% CI) being 0.56 (0.32-0.97). <br/><b>Conclusion</b>: We found a significant association between XRCC1399Gln/Gln and ADPRT 762Ala/Ala polymorphisms and clinical outcomes. These two genotypes could be used as asurrogate markers of clinical outcome in glioma cases receiving chemotherapy.