Schistosomiasis Combined with Colorectal Carcinoma Diagnosed Based on Endoscopic Findings and Clinicopathological Characteristics: A Report on 32 Cases

Abstract

Aims and <b>Background:</b> To improve understanding of the relationship between schistosome-related enteropathyand colorectal carcinoma with particular focus on endoscopic findings and clinicopathological characteristics ofcolonic schistosomiasis. Materials and <br/><b>Methods</b>: All cases of intestinal schistosomiasis diagnosed at West ChinaHospital, Chengdu, China, between October 2006 and October 2012 were included in this study. A total of 179cases of colonic schistosomiasis diagnosed through colonoscopy and pathological examinations were collectedfor analysis and the demographics, symptoms, endoscopic findings and clinicopathological characteristics wereretrospectively evaluated. <br/><b>Results</b>: Of the 179 colonic schistosomiasis patients, 32 combined with colorectalcancer (CRC) were found, between the ages of 44 and 85 years (24 males, 75%). These 32 lesions were classifiedas 12 endophytic/ulcerative (37.5%), 10 exophytic/fungating (31.2%), 4 annular (12.5%), 3 giant polypus (9.4%),and 3 Ⅱc (superficial depressed type) (9.4%). The segments of rectum and sigmoid colon were involved in 19patients (59.4%) and 6 patients (18.8%), respectively. The histopathologic types were classified as follows: 30 welldifferentiatedadenocarcinomas, one mucinous adenocarcinoma and one poorly differentiated adenocarcinoma.The pathological findings suggest colorectal malignancy with deposited schistosome ova. <br/><b>Conclusions</b>: Chronicschistosomal infestation has a probable etiological role in promoting genesis of colorectal neoplasms.