Genetic Variation in PDCD6 and Susceptibility to Lung Cancer

Abstract

Lung cancer is the most common type of cancer and one of the leading causes of death in the world. Geneticfactors play an important role in its development. PDCD6, the encoding gene for programmed cell death protein6, may function as a tumor suppressor gene. Non-small cell lung cancer (NSCLC) contributes about 80% tonewly histologically diagnosed lung cancer patients. To explore the relationship between PDCD6 and NSCLC,we examined two single nucleotide polymorphisms(rs3756712 G/T andrs4957014 G/T, both in the intron region)of the PDCD6gene.A hospital-based case-control study was carried out including 302 unrelated NSCLC patientsand 306 healthy unrelated subjects. Significantly increased NSCLC risk was found to be associated with the Tallele of rs4957014 (P=0.027, OR=0.760, 95%CI=0.596-0.970). The genotype and allele frequencies of rs3756712did not shown any significant difference between NSCLC group and controls (P=0.327, OR=0.879, 95%CI=0.679-1.137). In conclusion, we firstly demonstrated the association between the PDCD6 gene and risk of NSCLC ina Chinese Han population.