Glutathione-S-Transferase T1 Polymorphism is Associated with Esophageal Cancer Risk in Chinese Han Population

Abstract

<b>Background:</b> Glutathione-S-Transferase T1 (GSTT1) gene has been shown to be involved in the developmentof esophageal cancer. However, the results have been inconsistent. In this study, the authors performed a metaanalysisto clarify the association between GSTT1 polymorphism and esophageal cancer risk among ChineseHan population. <br/><b>Methods</b>: Published literature from PubMed, the China National Knowledge Infrastructureand Wanfang Data were searched. Pooled odds ratio (OR) and 95% confidence interval (95%CI) was calculatedusing a fixed- or random-effects model. <br/><b>Results</b>: Eleven studies with a total of 2779 individuals were included inthe meta-analysis. The results showed that GSTT1 null genotype was significantly associated with esophagealcancer risk in Chinese (OR = 1.31, 95%CI 1.12 to 1.53, p = 0.001). Further sensitivity analyses confirmed thesignificant association. The cumulative meta-analysis showed a trend of an obvious association between GSTT1null genotype and esophageal cancer risk as information accumulated by year. <br/><b>Conclusions</b>: This meta-analysissuggests a significant association of GSTT1 null genotype with esophageal cancer risk in the Chinese Hanpopulation.