Association of the miRNA146a rs2910164 C>G Polymorphism with Head and Neck Cancer Risk: A Meta-analysis

Abstract

<br/><b>Objective</b>: To investigate any association of the miRNA146a rs2910164 C>G polymorphism with head andneck cancer risk. Materials and <br/><b>Methods</b>: The Medline, PubMed, PUBMED, EMBASE, Web of Science, WanFangand CNKI databases were searched and a meta-analysis was conducted using RevMan 5.2 software. <br/><b>Results</b>:After searching and evaluating the literature, a total seven papers involving 2,766 patients with head and neckcancer and 6,603 healthy controls were included into this meta analysis. The results showed that there wereno significant differences between patients and healthy controls overall for the miRNA rs2910164 C>G genepolymorphism (dominant model:OR=0.78, 95%CI:0.58-1.04, P=0.09; recessive model:OR=0.86, 95%CI:0.67-1.12,P=0.27;GG:CC:OR=0.75, 95%CI:0.52-1.08, P=0.12;GC:CC:OR=0.79, 95%CI:0.60-1.04, P=0.10). However, asignificant association of miRNA rs2910164 C>G gene polymorphism with Chinese head and neck cancer risk wasnoted, limited to the dominant model (OR=0.68, 95%CI:0.50-0.95, P=0.02;GG:CC:OR=0.62, 95%CI:0.42-0.92,P=0.02;GC:CC:OR=0.72, 95%CI:0.520.99, P=0.04). <br/><b>Conclusions</b>: miRNA146a rs2910164 C>G polymorphismis not associated with head and neck cancer risk in general, but tehre may be link in Chinese.