KAI1/CD82 and MRP1/CD9 Serve as Markers of Infiltration, Metastasis, and Prognosis in Laryngeal Squamous Cell Carcinomas

Abstract

<br/><b>Objective</b>: The current study explored the expression of KAI1/CD82 and MRP1/CD9 and its significance inlaryngeal squamous cell carcinoma (LSCC). <br/><b>Methods</b>: The expression levels of KAI1/CD82 and MRP1/CD9 in 100LSCC tissue specimens, as well as in 30 para-LSCC non-carcinomatous tissue specimens randomly taken fromthe patients, were assessed using the quantitative polymerase chain reaction (Q-PCR) and immunohistochemistryand correlations with pathological parameters of LSCC and their influence on survival function were analyzed.<br/><b>Results</b>: KAI1/CD82 and MRP1/CD9 showed basically consistent changes in both mRNA and protein expression.Their expression in the 30 LSCC specimens was significantly lower compared with that in the correspondingnon-carcinous tissues (P < 0.01 or 0.05), notably correlating with TNM stage, differentiation degree, clinicalstage, and lymphatic metastasis (P < 0.01 or 0.05), but not gender, age, and LSCC growth sites (P > 0.05). Themedian survival of patients with positive KAI1/CD82 and MRP1/CD9 protein expression was longer than that ofpatients with negative protein expression (P < 0.01 or 0.05). KAI1/CD82 protein expression negatively correlatedwith MRP1/CD9 protein expression in LSCC (χ2= 31.25, P < 0.01). <br/><b>Conclusion</b>: KAI1/CD82 and MRP1/CD9may jointly participate in the development of LSCC. They may serve as the markers for judging the infiltration,metastasis, and prognosis of LSCC.