Interleukin 10 rs1800872 T>G Polymorphism was Associated with an Increased Risk of Esophageal Cancer in a Chinese Population

Abstract

Aim: Esophageal cancer is the eighth most common cancer and sixth leading cause of cancer associateddeath worldwide. The 5 year survival rate for esophageal cancer patients is very poor and accounts for only12.3%. Besides environmental risk factors, genetic factors might play an important role in the esophageal cancercarcinogenesis. <br/><b>Methods</b>: We conducted a hospital based case–control study to evaluate the genetic effects offunctional single nucleotide polymorphisms (SNPs): interleukin 9 (IL9) rs31563 C>T, IL9 rs31564 G>T, IL10rs1800872 T>G, IL12A rs2243115 T>G, IL12B rs3212227 T>G and IL13 rs1800925 C>T on the developmentof esophageal cancer. A total of 380 esophageal squamous cell carcinoma (ESCC) cases and 380 controls wererecruited for this study. The genotypes were determined using a custom-by-design 48-Plex SNPscanTM Kit. <br/><b>Results</b>:The IL10 rs1800872 T>G polymorphism was associated with an increased risk of ESCC. However, there were nosignificant links with the other five SNPs. Stratified analyses indicated no significant risk of ESCC associated withthe IL10 rs1800872 T>G polymorphism evident among any subgroups. <br/><b>Conclusion</b>: These findings indicated thatfunctional polymorphism IL10 rs1800872 T>G might contribute to ESCC susceptibility. However, our resultswere obtained with a limited sample size, so that the power of our analysis was low. Future larger studies withmore rigorous study designs of other ethnic populations are required to confirm the current findings.