Lack of Relation of AKAP12 with p53 and Bcl-2 in Colorectal Carcinoma

Abstract

<b>Background:</b> AKAP12 inhibits oncogenic proliferation, invasion, chemotaxis and neovascularization. Bcl-2 andp53 are two important apoptotic markers that play roles in apoptotic processes. It has been found that AKAP12blocks the cell cycle and induces apoptosis in fibrosarcoma cells. In our study we assessed the relationship ofAKAP12 with apoptotic markers, Bcl-2 and p53. Materials and <br/><b>Methods</b>: Our study included 45 cases that werehistopathologically diagnosed with colorectal carcinoma from the tissue samples acquired by surgical resection.AKAP 12, Bcl-2, and p53 expression was examined by immunohistochemistry. <br/><b>Results</b>: A total of 45 colorectaladenocarcinoma patients - 17 (37.8%) females and 28 (62.2%) males - were included in this study. AKAP12expression was found to be negative in 8 patients (17.8%), and positive in 37 patients (82.2%). Bcl-2 was foundpositive in 6 patients (13.3%) and p53 in 29 patients (55.6%). AKAP12 expression had no significant relation withBcl-2 and p53 expression (p:0.939, p:0.079, respectively). <br/><b>Conclusions</b>: Although various studies have pointed toapoptotic activity of AKAP12, the literature is limited regarding relations with p53 or Bcl-2 expression. In thepresent study, we found no relation in colorectal carcinomas.