نمایش مختصر رکورد

dc.contributor.authorEl Din Fouad, Neveen Bahaaen_US
dc.contributor.authorIbrahim, Noha Yehiaen_US
dc.contributor.authorAbdel Aziz, Rania Salahen_US
dc.contributor.authorIbrahim, Sarah Khaliden_US
dc.date.accessioned1399-07-08T18:06:15Zfa_IR
dc.date.accessioned2020-09-29T18:06:15Z
dc.date.available1399-07-08T18:06:15Zfa_IR
dc.date.available2020-09-29T18:06:15Z
dc.date.issued2018-12-01en_US
dc.date.issued1397-09-10fa_IR
dc.date.submitted2017-11-06en_US
dc.date.submitted1396-08-15fa_IR
dc.identifier.citationEl Din Fouad, Neveen Bahaa, Ibrahim, Noha Yehia, Abdel Aziz, Rania Salah, Ibrahim, Sarah Khalid. (2018). CD200 Expression in Diagnostic and Prognostic Assessment of Mature B Cell Lymphophoproliferative Neoplasms. Asian Pacific Journal of Cancer Prevention, 19(12), 3383-3392. doi: 10.31557/APJCP.2018.19.12.3383en_US
dc.identifier.issn1513-7368
dc.identifier.issn2476-762X
dc.identifier.urihttps://dx.doi.org/10.31557/APJCP.2018.19.12.3383
dc.identifier.urihttp://journal.waocp.org/article_77404.html
dc.identifier.urihttps://iranjournals.nlai.ir/handle/123456789/36298
dc.description.abstractBackground: Multiparameter flow cytometry is a useful tool for diagnostic evaluation of mature B-cell neoplasms<br />(MBN). Recently, it has been shown that assessment of CD200 expression may improve the distinction between<br />chronic lymphocytic leukemia (CLL; CD200 positive) and mantle cell lymphoma (MCL; CD200 negative), but any<br />potential as a prognostic marker for CLL remains to be established. Materials and methods: This cross sectional<br />study was conducted on sixty-seven patients newly diagnosed as having mature B-cell lymphoproliferative disorders<br />Levels of CD 200 in lymphoma cells were assessed. Results: CD200 was consistently expressed in CLL and hairy<br />cell leukemia B cells, but not in MCL cells. Heterogeneous expression was noted in other CD5 positive Non-Hodgkin<br />lymphomas. High CD200 expression (≥50%) was associated with a higher CD5, 19 and CD23 expression, older<br />age, higher TLC and absolute lymphocyte count, hepatomegaly, splenomegaly and a higher Rai stage. There were<br />no significant correlations between CD200 expression and response to treatment. Conclusion: CD200 could be of high<br />value in distinguishing CLL, MCL, and atypical CLL. CD200 expression can also be of prognostic and therapeutic<br />value in CLL cases.en_US
dc.format.extent524
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoen_US
dc.publisherWest Asia Organization for Cancer Prevention (WAOCP)en_US
dc.relation.ispartofAsian Pacific Journal of Cancer Preventionen_US
dc.relation.isversionofhttps://dx.doi.org/10.31557/APJCP.2018.19.12.3383
dc.subjectCD200en_US
dc.subjectMature B-cell neoplasmsen_US
dc.subjectFlowcytometryen_US
dc.subjectCLLen_US
dc.subjectHematologic Oncologyen_US
dc.titleCD200 Expression in Diagnostic and Prognostic Assessment of Mature B Cell Lymphophoproliferative Neoplasmsen_US
dc.typeTexten_US
dc.typeResearch Articlesen_US
dc.contributor.departmentClinical Pathology Department, Faulty of Medicine, Cairo University, Egypt.en_US
dc.contributor.departmentClinical Oncology Department (NEMROCK), Cairo University, Egypt.en_US
dc.contributor.departmentClinical Pathology Department, National Cancer Institute (NCI), Cairo University, Egypt.en_US
dc.contributor.departmentClinical Pathology Department, National Cancer Institute (NCI), Cairo University, Egypt.en_US
dc.citation.volume19
dc.citation.issue12
dc.citation.spage3383
dc.citation.epage3392
nlai.contributor.orcid0000-0003-3291-0036


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