Analysis on Postoperative Efficacy of Radical Hepatectomy for Patients with Non-HBV/HCV Hepatocellular Carcinoma

Abstract

<br/><b>Objective</b>: Patients with hepatocellular carcinoma (HCC) in stage Barcelona Clinic Liver Cancer (BCLC)-Awere grouped based on whether they were accompanied with hepatitis B virus (HBV) infection or not so as toexplore the clinical characteristics and prognostic conditions of HCC patients with non-HBV/hepatitis C virus(HCV). Materials and <br/><b>Methods</b>: Clinical data of 64 stage BCLC-A HCC patients with non-HBV/HCV infection(observation group) who received radical hepatectomy in the Affiliated Cancer Hospital of Guangxi MedicalUniversity from January, 2006 to November, 2014 were retrospectively analyzed and compared with those of409 stage BCLC-A HCC patients with HBV infection (control group) in corresponding period. <br/><b>Results</b>: Thepostoperative 1-, 3- and 5-year recurrent rates of the observation group were 25%, 38.6% and 48.8%, withpostoperative mean and median disease-free survival time being 49.1 months and 62.0 months, respectively.Additionally, the postoperative 1-, 3- and 5-year survival rates of observation group were 90.1%, 72.7% and62.0%, with the mean and median survival times being 54.4 months and 70.0 months, respectively. <br/><b>Conclusions</b>:The 1-year recurrent rate is the highest in HCC patients with non-HBV/HCV, and almost half of the patientshave recurrence within 1 year, after which the recurrent rate decreases along with the time.