Low Prevalence of Human Papilloma Virus in Patients with Breast Cancer, Kerman; Iran

Abstract

Breast cancer is the first of the most important causes of the deaths of women in the world and in Iran. There are<br />various causes and causes of this cancer, one of which has recently been described as a cause of breast cancer, is the human<br />papillomavirus (HPV). The HPV is transmitted through sexual contact and skin lesions. There are more than 100 types of<br />HPV that can influence different parts of the body. Some types of HPV can cause cancer (such as cervical or anal cancer)<br />and others can cause warts (such as genital or plantar warts). To study the risk of HPV infection in Breast Cancer, we<br />managed a Case-Control study in Kerman, southeast of Iran. For this purpose, 98 paraffin blocks of breast cancer and<br />40 paraffin blocks of fibrocystic as a control were tested for the presence of HPV DNA using Real-Time PCR, and<br />HPV typing was done using INNo-Lippa assay. HPV DNA was detected in 8 out of 98 patients (8.2%), while it was<br />not detected in the control group samples. HPV types 16, 18 were the most common (62.5%) types in positive samples.<br />The prevalence of HPV in patients with breast cancer of Iran is very low and less than other regions of the world,<br />it seems that maybe rout of transmission of HPV in Iran is under control. No one knows exactly why breast cancer<br />occurs. The environment, hormones, Viruses, or your lifestyle could all play a role in the development of breast cancer.<br />Currently, Vaccination is the best way to prevent cancer that's due to HPV. However, additional studies on the larger<br />group of patients are needed to explain the roles of HPV in Breast cancer.