The C Allele of a Synonymous SNP (rs1805414, Ala284Ala) in PARP1 is a Risk Factor for Susceptibility to Breast Cancer in Saudi Patients

Abstract

<b>Background:</b> Genetic aberrations of DNA repair enzymes are known to be common events associatedwith different cancer entities. The aim of the present study was to analyze genetic associations of rs1805404(Asp81Asp) and rs1805414 (Ala284Ala) in the PARP1 gene with the risk of breast cancer in Saudi Arabia.Materials and <br/><b>Methods</b>: These two SNP’s were analyzed in a primary study group of breast cancer patients andhealthy control subjects. Genotypes were determined by TaqMan SNP testing and analyzed using Chi-squareor t test and logistic regression analysis with SPSS16.0 software. Results and <br/><b>Conclusions</b>: Results showed thatrs1805414 was associated with a significantly increased susceptibility to breast cancer, significant risk beingobserved for the TC, CC and TC+CC genotypes. In conclusion PARP1 rs1805414 SNP polymorphisms may beinvolved in the etiology of breast cancer in the Saudi population. In contrast, PARP1 rs1805404 did not showany significant association in overall in breast cancer samples when compared to healthy controls. Confirmationof our findings in larger populations of different ethnicities may provide evidence for a role of the PARP1 genein breast carcinoma developnment.