Determination of Captopril using platinum coated nanoporous gold film electrode

Abstract

In this article electrochemical determination of captopril at the surface of the platinum coated nanoporous gold film (PtNPGF) electrode is reported using the cyclic voltammetry and amperometry. For the preparation of PtNPGF, the surface of NPGF electrode was covered with Cu layer using underpotential electrochemical deposition (UPD).Afterward, the copper layer is replaced with platinum ions via a spontaneous redox reaction to have a uniform Ptoverlayer. Under the optimized conditions, the amperometry peak current of captopril increased linearly with captopril concentration in the ranges of 4.70×10-8 to 4.57×10-5mol L−1. The detection limit of captopril was 1.2×10-8mol L−1. The results show a very good precision (R.S.D < 2.4%), suitable selectivity and very stable response for captopril. The proposed sensor was successfully applied for the determination of captopril in the urine samples of patient human.