PIK3CA and PTEN Genes Expressions in Breast Cancer

Abstract

Background: The phosphatidylinositol-3 kinase (PI3K) intracellular signaling pathway plays an important<br />role in breast cancer. The current study aimed to evaluate the expressions of two main regulators of PI3K pathway;<br />phosphatidylinositol-3- kinase catalytic subunit alpha as activator (PIK3CA), and phosphatase and tensin-homolog<br />as inhibitor (PTEN), in breast carcinoma tissue, and compare with their expressions in adjacent normal breast tissue.<br />Methods: A total of fifty female patients with breast carcinoma from surgical oncology unit of Alexandria-Main<br />University Hospital were included in this study. The Quantitative Real Time PCR was used to quantify expressions of<br />PIK3CA and PTEN. Results: PIK3CA mRNA expression was significantly increased in breast cancer tissues compared<br />to normal breast tissues (P<0.001, Z=5.700), also PTEN mRNA expression was significantly higher in breast carcinoma<br />tissue compared to normal breast tissue (P<0.001, Z=5.362). Conclusion: Increased the expressions of PIK3CA and<br />PTEN mRNA in breast cancer tissue compared to normal breast tissue.