The GSTT1 Null Genotype Contributes to Increased Risk of Prostate Cancer in Asians: a Meta-analysis

Abstract

<b>Background:</b> Many studies have investigated the association between glutathione S-transferase T 1 (GSTT1)null genotype and risk of prostate cancer, but the impact of GSTT1 null genotype in Asians is still unclear owingto inconsistencies across results. Thie present meta-analysis aimed to quantify the strength of the associationbetween GSTT1 null genotype and risk of prostate cancer. <br/><b>Methods</b>: We searched the PubMed, Embase andWangfang databases for studies of associations between the GSTT1 null genotype and risk of prostate cancer inAsians and estimated summary odds ratio (OR) with their 95% confidence interval (95% CI). <br/><b>Results</b>: A totalof 11 case-control studies with 3,118 subjects were included in this meta-analysis, which showed the GSTT1null genotype to be significantly associated with increased risk of prostate cancer in Asians (random-effects OR= 1.49, 95% CI 1.15-1.92, P = 0.002), also after adjustment for heterogeneity (fixed-effects OR = 1.45, 95% CI1.23-1.70, P < 0.001). No evidence of publication bias was observed. <br/><b>Conclusions</b>: This meta-analysis of availabledata suggested the GSTT1 null genotype does contribute to increased risk of prostate cancer in Asians.