Polymorphisms of XRCC3 and XRCC7 and Colorectal Cancer Risk in Khorasan Razavi Province, Iran

Abstract

Background: Colorectal cancer (CRC) is highly prevalent cancer, which should be genetically studied among<br />different peoples of the world. Objective: The aim of this study was to evaluate the effect of XRCC3T241M, XRCC3<br />A17893G and, for the first time, XRCC7 I3434T polymorphisms on CRC risk in Khorasan Razavi Province, Iran.<br />Materials and Methods: In this case-control study, 180 patients with CRC and 160 sex- and age-matched healthy<br />controls were studied. Genotypes were determined by RFLP-PCR and ARMS-PCR. Results: The incidence of CRC was<br />observed to be significantly more in a heterozygous XRCC3 C/T genotype than in the CC genotype (OR 2.210, 95% CI<br />1.073-4.548, p=0.030). In the case of the XRCC7 I3434T polymorphism, CRC risk was significantly (4.3 fold) higher<br />in I/T+T/T variant subjects compared to the I/I genotype (OR 4.394, 95% CI 2.721-7.096, p=0.000). Moreover, the<br />XRCC3 A17893G polymorphism did not correlate with CRC. In addition, there was no significant difference between<br />the distribution of genotypes of the three studied polymorphisms with demographic and clinicopathological features<br />in the CRC patients. Conclu