نمایش مختصر رکورد

dc.date.accessioned1399-07-08T18:00:56Zfa_IR
dc.date.accessioned2020-09-29T18:00:56Z
dc.date.available1399-07-08T18:00:56Zfa_IR
dc.date.available2020-09-29T18:00:56Z
dc.date.issued2014-05-01en_US
dc.date.issued1393-02-11fa_IR
dc.identifier.citation(2014). Prognostic Role of Nucleophosmin in Colorectal Carcinomas. Asian Pacific Journal of Cancer Prevention, 15(5), 2021-2026.en_US
dc.identifier.issn1513-7368
dc.identifier.issn2476-762X
dc.identifier.urihttp://journal.waocp.org/article_28870.html
dc.identifier.urihttps://iranjournals.nlai.ir/handle/123456789/34319
dc.description.abstractAim: Recent research suggests that nucleophosmin (NPM) may be a prognostic marker in colorectalcarcinomas (CRC). We here tested its use to predict the survival of CRC patients. <br/><b>Methods</b>: We investigatedNPM expression by immunohistochemistry in histologically normal to malignant colorectal tissues and evaluatedits association with clinicopathological variables. Overall and disease-free survival after tumor removal werecalculated by the Kaplan-Meier method, and differences in survival curves were analyzed by the log-rank test.The Cox proportional hazards model was used for multivariate analysis of prognostic factors. <br/><b>Results</b>: NPMexpression was found significantly upregulated in CRC compared to adjacent colorectal tissue, villous adenoma,tubular adenoma and normal colorectal mucosa (p<0.05 for all). NPM expression was statistically linked tocancer embolus, lymph node metastasis, differentiation grade, and recurrence of CRC. Overall and disease-freesurvival of NPM-negative CRC patients tended to be better than those for patients with NPM-positive lesions(log-rank statistic, p<0.05 for all). Multivariate analysis indicated NPM expression as an independent prognosticindicator for CRC patients (p<0.05 ). <br/><b>Conclusion</b>: Our results suggest that NPM expression can predict thesurvival of CRC patients. Prognosis of CRC is determined by not only many known prognostic factors but alsoby NPM expression.en_US
dc.format.extent1902
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoen_US
dc.publisherWest Asia Organization for Cancer Prevention (WAOCP)en_US
dc.relation.ispartofAsian Pacific Journal of Cancer Preventionen_US
dc.subjectNucleophosminen_US
dc.subjectPrognosisen_US
dc.subjectcolorectal carcinomasen_US
dc.titlePrognostic Role of Nucleophosmin in Colorectal Carcinomasen_US
dc.typeTexten_US
dc.citation.volume15
dc.citation.issue5
dc.citation.spage2021
dc.citation.epage2026


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