Levels of Pro and Anti-inflammatory Citokynes and C-Reactive Protein in Patients with Chronic Periodontitis Submitted to Nonsurgical Periodontal Treatment
(ندگان)پدیدآور
Escobar, Gustavo FaturetoAbdalla, Douglas ReisBeghini, MarcelaGotti, Valeria BisinotoRodrigues Junior, VirmondesNapimoga, Marcelo HenriqueRibeiro, Betania MariaRodrigues, Denise Bertulucci RochaNogueira, Ruchele DiasPereira, Sanivia Aparecida de Limaنوع مدرک
TextResearch Articles
زبان مدرک
Englishچکیده
Aim: to compare the levels of IFN-γ, TGF-β and C-reactive protein (CRP) in healthy patients (HP) and chronicperiodontitis patients (CP) before and seven days after the last session of Non-Surgical Periodontal Treatment (NSPT).Materials and Methods: 40 subjects were divided into two groups: healthy (n= 20), and with chronic periodontitis(n = 20). Serum and gingival crevicular fluid (GCF) were collected from each patient and quantified for IFN-γ,TGF-β and CRP using the enzyme-linked immunosorbent assay (ELISA). Results: IFN-γ was found to be higher inthe GCF of the CP group before NSPT in relation to the HP group (pseven days of NSPT (pwhen compared to HP (p0.05). Serum CRP levels did not showstatistical difference between CP and HP before or after NSPT. Conclusion: Therefore, our results demonstrated forthe first time that NSPT causes early exacerbation of the immune response at the local level represented by increasedlevels of IFN-γ and decreased levels of TGF-β in the gingival crevicular fluid after seven days of treatment.
کلید واژگان
C-reactive proteinCytokines
immune system
Inflammation
Periodontitis
Dentistry
شماره نشریه
7تاریخ نشر
2018-07-011397-04-10
ناشر
West Asia Organization for Cancer Prevention (WAOCP)سازمان پدید آورنده
University of Uberaba, Uberaba, MG, Brazil.University of Uberaba, Uberaba, MG, Brazil.
Cefores, Federal University of Triângulo Mineiro, Uberaba, MG, Brazil.
Centro Universitário do Triângulo, Uberlândia, MG, Brazil.
Cefores, Federal University of Triângulo Mineiro, Uberaba, MG, Brazil.
São Leopoldo Mandic Institute and Research Center, Campinas, SP, Brazil.
Cefores, Federal University of Triângulo Mineiro, Uberaba, MG, Brazil.
University of Uberaba, Uberaba, MG, Brazil.
University of Uberaba, Uberaba, MG, Brazil.
University of Uberaba, Uberaba, MG, Brazil.
شاپا
1513-73682476-762X