نمایش مختصر رکورد

dc.date.accessioned1399-07-09T08:26:29Zfa_IR
dc.date.accessioned2020-09-30T08:26:29Z
dc.date.available1399-07-09T08:26:29Zfa_IR
dc.date.available2020-09-30T08:26:29Z
dc.date.issued2014-01-01en_US
dc.date.issued1392-10-11fa_IR
dc.date.submitted2014-08-20en_US
dc.date.submitted1393-05-29fa_IR
dc.identifier.citation(2014). A Three-Component 1,3-Dipolar Cycloaddition Reaction of Azomethine Ylide for Synthesis of New Bis-spiro-oxindolo(pyrrolizidines/pyrrolidines) Derivatives. International Journal of Bio-Inorganic Hybrid Nanomaterials, 3(4), 231-238.en_US
dc.identifier.issn2251-8533
dc.identifier.issn2322-4142
dc.identifier.urihttp://ijbihn.iauvaramin.ac.ir/article_641379.html
dc.identifier.urihttps://iranjournals.nlai.ir/handle/123456789/341456
dc.description.abstractThe development of multicomponent reactions (MCRs) designed to produce elaborate biologically active compounds has become an important area of research in organic, combinatorial, and medicinal chemistry. A comparative study of the synthesis of new bis-spiro-oxindolo(pyrrolizidines/pyrrolidines) ring systems by the cycloaddition of azomethine ylides generated by a decarboxylative route from sarcosine/proline and isatin with the bis-chalcone using various conditions is described. As part of our endeavor to synthesize new bis-spiro-oxindolo(pyrrolizidines/pyrrolidines) derivatives containing two spiro carbons which often enhances the biocidal profile or may create new medicinal properties remarkably. Herein we report the facile synthesis of bis-spiro-oxindolo(pyrrolizidines/pyrrolidines) derivatives, in a highly regio- and stereoselective manner through 1,3-dipolar cycloaddition reaction of bis-dipolarophiles with the 1,3-dipole generated from isatin derivatives and secondary amino acids (L-proline or sarcosine). The structures of cycloaddition products were assigned by IR, 1HNMR, 13CNMR and Mass spectral data.en_US
dc.format.extent412
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoen_US
dc.publisherIslamic Azad University - Varamin Branchen_US
dc.relation.ispartofInternational Journal of Bio-Inorganic Hybrid Nanomaterialsen_US
dc.subjectAzomethine ylidesen_US
dc.subjectBis-dipolarophilesen_US
dc.subjectBis-spiro-oxindolo(pyrrolizidines/pyrrolidines)en_US
dc.subjectSarcosineen_US
dc.subjectProlineen_US
dc.titleA Three-Component 1,3-Dipolar Cycloaddition Reaction of Azomethine Ylide for Synthesis of New Bis-spiro-oxindolo(pyrrolizidines/pyrrolidines) Derivativesen_US
dc.typeTexten_US
dc.typeResearch Paperen_US
dc.citation.volume3
dc.citation.issue4
dc.citation.spage231
dc.citation.epage238


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