Development of 177Lu-phytate Complex for Radiosynovectomy

Abstract

<em>Objective(s):</em> In this work a new possible agent for radiosynovectomy has been targeted for articular pain palliation. <br/><em>Materials and Methods:</em> Lu-177 of 2.6-3 GBq/mg specific activity was obtained by irradiation of natural Lu₂O₃sample with thermal neutron flux of 4 × 10¹³ n.cm^-2.s^-1. The product was converted into chloride form which was further used for labeling of ¹⁷⁷Lu-phytate complex and checked using ITLC (MeOH: H₂O: acetic acid, 4: 4: 2, as mobile phase). The complex stability and viscosity were checked in the final solution up to seven days. The prepared complex solution (100 µCi/100 µl) was injected intra-articularly to male rat knee joint. Leakage of radioactivity from injection site and its distribution in organs were investigated up to seven days. <br/><em>Results:</em> The complex was successfully prepared with high radiochemical purity (>99.9 %). Approximately, the whole injected dose has remained in injection site seven days after injection. <br/><em>Conclusion: </em>The complex was proved to be a feasible agent for cavital radiotherapy in oncology and rheumatology