نمایش مختصر رکورد

dc.contributor.authorKianifard, Davouden_US
dc.contributor.authorSadrkhanlou, Rajab Alien_US
dc.contributor.authorHasanzadeh, Shapouren_US
dc.date.accessioned1399-07-09T08:23:13Zfa_IR
dc.date.accessioned2020-09-30T08:23:13Z
dc.date.available1399-07-09T08:23:13Zfa_IR
dc.date.available2020-09-30T08:23:13Z
dc.date.issued2012-01-01en_US
dc.date.issued1390-10-11fa_IR
dc.date.submitted2015-09-14en_US
dc.date.submitted1394-06-23fa_IR
dc.identifier.citationKianifard, Davoud, Sadrkhanlou, Rajab Ali, Hasanzadeh, Shapour. (2012). The Ultrastructural Changes of the Sertoli and Leydig Cells Following Streptozotocin Induced Diabetes. Iranian Journal of Basic Medical Sciences, 15(1), 623-635. doi: 10.22038/ijbms.2012.4831en_US
dc.identifier.issn2008-3866
dc.identifier.issn2008-3874
dc.identifier.urihttps://dx.doi.org/10.22038/ijbms.2012.4831
dc.identifier.urihttp://ijbms.mums.ac.ir/article_4831.html
dc.identifier.urihttps://iranjournals.nlai.ir/handle/123456789/340438
dc.description.abstractObjective(s) This investigation was conducted to evaluate the effects of diabetes on the structure and function of testicular tissue. Materials and Methods Diabetes was induced in male adult rats by a single intraperitoneal injection of streptozotocin. Body and testicular weight, hormonal analyses, histological and ultrastructural analyses were measured. Results The body and testicular weights were dropped significantly (<em>P</em>< 0.05) in diabetic rats in comparison with control rats. On the other hand, in diabetic rats, the blood glucose level increased significantly (<em>P</em>< 0.05). The blood plasma levels of testosterone, 17-β estradiol, progesterone, FSH and LH were reduced in diabetic rats. Histomorphological studies were revealed reduction in diameter of seminiferous tubules and germinal epithelium height, edema in interstitial tissue, germ cell depletion, decrease in cellular population and activity with disruption of spermatogenesis in diabetic rats. Ultrastructural study showed the mitochondrial change and reduction of smooth endoplasmic reticulum in Sertoli and presence of lipid droplets in Leydig cells of diabetic rat's testes. Conclusion The results of the present study confirmed that, the ultrastructural changes of Sertoli and Leydig cells, brought about by streptozotocin induced diabetes, because of the alterations in pituitary gonadotropins, and these changes influence the normal spermatogenesis in rats.en_US
dc.format.extent1088
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoen_US
dc.publisherMashhad University of Medical Sciencesen_US
dc.relation.ispartofIranian Journal of Basic Medical Sciencesen_US
dc.relation.isversionofhttps://dx.doi.org/10.22038/ijbms.2012.4831
dc.subjectDiabetesen_US
dc.subjectElectron Microscopyen_US
dc.subjectLeydig cellen_US
dc.subjectSertoli cellen_US
dc.subjectTestisen_US
dc.titleThe Ultrastructural Changes of the Sertoli and Leydig Cells Following Streptozotocin Induced Diabetesen_US
dc.typeTexten_US
dc.typeOriginal Articleen_US
dc.contributor.departmentDepartment of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iranen_US
dc.contributor.departmentDepartment of Basic Sciences, Histology and Embryology Sections, Faculty of Veterinary Medicine, Urmia University, Urmia, Iranen_US
dc.contributor.departmentDepartment of Basic Sciences, Histology and Embryology Sections, Faculty of Veterinary Medicine, Urmia University, Urmia, Iranen_US
dc.citation.volume15
dc.citation.issue1
dc.citation.spage623
dc.citation.epage635


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