Nephroprotective effects of Feijoa Sellowiana leaves extract on renal injury induced by acute dose of ecstasy (MDMA) in mice

Abstract

<br/> <br/> <br/> <br/> <br/><em><span style="font-size: xx-small;">Objective(s): </span></em><span style="font-family: Cambria,Cambria; font-size: xx-small;"><span style="font-family: Cambria,Cambria; font-size: xx-small;">Because of the high total phenolic contents of </span></span><em><span style="font-family: Cambria,Cambria; font-size: xx-small;"><em><span style="font-family: Cambria,Cambria; font-size: xx-small;">Feijoa sellowiana</span></em></span></em> <br/><span style="font-family: Cambria,Cambria; font-size: xx-small;">, its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (MDMA) treated mice. </span> <br/> <br/>Materials and Methods: <br/><span style="font-family: Cambria,Cambria; font-size: xx-small;"><span style="font-family: Cambria,Cambria; font-size: xx-small;">Animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of </span></span><em><span style="font-family: Cambria,Cambria; font-size: xx-small;"><em><span style="font-family: Cambria,Cambria; font-size: xx-small;">F. sellowiana </span></em></span></em> <br/><span style="font-family: Cambria,Cambria; font-size: xx-small;">leaves, intra-peritoneally. After one hour, an acute administration of MDMA (20 mg/kg, IP) was injected. Nephroprotective effect was assayed by determination of serum creatinine, serum urea and kidney glutathione level. Histopathological study was also used. </span> <br/> <br/>Results <br/> <br/><span style="font-family: Cambria,Cambria; font-size: xx-small;"><span style="font-family: Cambria,Cambria; font-size: xx-small;">: </span></span><span style="font-family: Cambria,Cambria; font-size: xx-small;"><span style="font-family: Cambria,Cambria; font-size: xx-small;">Both extracts at 40 mg/kg resulted in a significant reversal in the raised serum creatinine levels (</span></span><em><span style="font-family: Cambria,Cambria; font-size: xx-small;"><em><span style="font-family: Cambria,Cambria; font-size: xx-small;">P </span></em></span></em><span style="font-family: Cambria,Cambria; font-size: xx-small;"><span style="font-family: Cambria,Cambria; font-size: xx-small;"><0.05). Not statistically significant was observed in effect of two extracts (</span></span><em><span style="font-family: Cambria,Cambria; font-size: xx-small;"><em><span style="font-family: Cambria,Cambria; font-size: xx-small;">P</span></em></span></em><span style="font-family: Cambria,Cambria; font-size: xx-small;"><span style="font-family: Cambria,Cambria; font-size: xx-small;">>0.05). A decrease in urea/ creatinine ratio was observed following aqueous extract treatment. Methanolic extract showed higher activity in increasing kidney glutathione (</span></span><em><span style="font-family: Cambria,Cambria; font-size: xx-small;"><em><span style="font-family: Cambria,Cambria; font-size: xx-small;">P</span></em></span></em> <br/><span style="font-family: Cambria,Cambria; font-size: xx-small;"> <br/>Conclusion: <br/> <br/><span style="font-family: Cambria,Cambria; font-size: xx-small;"><em><span style="font-family: Cambria,Cambria; font-size: xx-small;">F. sellowiana </span></em></span><span style="font-family: Cambria,Cambria; font-size: xx-small;"><span style="font-family: Cambria,Cambria; font-size: xx-small;">extract resulted in a markedly decrease in the nephrotoxicity of MDMA in mice. </span></span></span>