Volume 19, Issue 12
مرور بر اساس
ارسال های اخیر
-
Inhibition of Akt phosphorylation attenuates resistance to TNF-α cytotoxic effects in MCF-7 cells, but not in their doxorubicin resistant derivatives
(Mashhad University of Medical Sciences, 2016-12-01)Objective(s): Acquisition of TNF-α resistance plays role in the onset and growth of malignant tumors. Previous studies have demonstrated that MCF-7 cell line and its doxorubicin resistant variant ...
-
Volatile compounds analysis and antioxidant, antimicrobial and cytotoxic activities of Mindium laevigatum
(Mashhad University of Medical Sciences, 2016-12-01)Objective(s): Mindium laevigatum is an endemic plant of Iran and Turkey and is widely used as blood purifier, antiasthma and antidyspnea in traditional medicine. Chemical composition of ...
-
Dendrosomal nanocurcumin and p53 overexpression synergistically trigger apoptosis in glioblastoma cells
(Mashhad University of Medical Sciences, 2016-12-01)Objective(s): Glioblastoma is the most lethal tumor of the central nervous system. Here, we aimed to evaluate the effects of exogenous delivery of p53 and a nanoformulation of curcumin called ...
-
MicroRNA-297a regulates vascular calcification by targeting fibroblast growth factor 23
(Mashhad University of Medical Sciences, 2016-12-01)Objective(s): Vascular calcification is one the major characteristics in patients with various types of chronic inflammatory disorders. MiRNAs have been shown to be involved in many normal biological ...
-
Polysaccharide from Sepia esculenta ink and cisplatin inhibit synergistically proliferation and metastasis of triple-negative breast cancer MDA-MB-231 cells
(Mashhad University of Medical Sciences, 2016-12-01)Objective(s): This paper aims to investigate synergistic inhibition of polysaccharide from Sepia esculenta ink (SIP), a newly isolated marine polysaccharide in our laboratory, on breast ...
-
G-CSF for mobilizing transplanted bone marrow stem cells in rat model of Parkinson's disease
(Mashhad University of Medical Sciences, 2016-12-01)Objective(s): Granulocyte-colony stimulating factor (G-CSF) is used in clinical practice for the treatment of neutropenia and to stimulate generation of hematopoietic stem cells in bone marrow ...
-
Extra virgin olive oil in maternal diet increases osteogenic genes expression, but high amounts have deleterious effects on bones in mice offspring at adolescence
(Mashhad University of Medical Sciences, 2016-12-01)Objective(s): Maternal high-fat diet has been shown to have deleterious effects on the offspring bones. However, there is no study to assess the effects of type and amount of maternal dietary oil ...
-
Effect of A-769662, a direct AMPK activator, on Tlr-4 expression and activity in mice heart tissue
(Mashhad University of Medical Sciences, 2016-12-01)Objective(s): TLR-4 activates a number of inflammatory signaling pathways. Also, AMPK could be involved in anti-inflammatory signaling. The aim of this study was to identify whether stimulation ...
-
Survival, proliferation, and migration of human meningioma stem-like cells in a nanopeptide scaffold
(Mashhad University of Medical Sciences, 2016-12-01)Objective(s): In order to grow cells in a three-dimensional (3D) microenvironment, self-assembling peptides, such as PuraMatrix, have emerged with potential to mimic the extracellular matrix. The ...
-
Cinnamon effects on metabolic syndrome: a review based on its mechanisms
(Mashhad University of Medical Sciences, 2016-12-01)Objective(s): Nowadays, cardiovascular diseases (CVDs) are the major risk factors of death globally. One of the most undeniable reasons of CVDs is metabolic syndrome (MetS). MetS is defined as a ...
